Stem cell research holds tremendous promise for the development of novel therapies for many serious diseases and injuries. Stem cell research vol 22, pages 188 july 2017 sciencedirect. A common fate for multipotent stem cells is to remain quiescent without dividing or differentiating, thus maintaining its place in the stem cell. Welldefined synthetic hydrogels have emerged as promising vehicles for stem cell delivery. Stem cells wiley online library stem cells journals.
Based on the two defining characteristics of stem cells unlimited selfrenewal and ability to differentiate, they can be described as having four outcomes or fates 3 figure 2. Most downloaded stem cell research articles the most downloaded articles from stem cell research in the last 90 days. Here, we demonstrate the generation of ips cells from adult human dermal fibroblasts with the same four factors. As in animals, stem cells reside in stem cell niches, which produce signals that regulate the balance between selfrenewal and the generation of daughter cells that differentiate into new. Cell sources, characteristics, differentiation and therapeutic applications are discussed.
Stem cells have been widely studied in the fields of cancer biology. With a focus on stem cells of all tissue types and their potential therapeutic applications, the journal. Stem cell therapies hold considerable promise, but their clinical application is predicated on the development of appropriate delivery platforms. Embryonic stem es cells are cells derived from the early embryo that can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent. Receive an update when the latest issues in this journal are published. Building on success of its awardwinning preceding edition, the second edition features new chapters on embryonic and ips cells and stem cells. Evidence suggests that msc evs demonstrate potent protective effects mediated through a variety of mechanisms related to the transfer of evs cargo to the recipient cells. The genesis of stem cells is followed by laboratory steps of controlled stem cell. While stem cell based treatments have been established as a clinical standard of care for some conditions, such as hematopoietic stem cell transplants for leukemia and epithelial stem cell. Multipotentstem cells can form multiple types of cells. Stem cells is read and written by clinical and basic scientists whose expertise encompasses the rapidly expanding fields of stem and progenitor cell biology.
Mesenchymal stem cellderived extracellular vesicles for the treatment of acute respiratory distress syndrome aswin abraham anna krasnodembskaya wellcomewolfson institute for experimental medicine, queens university of belfast, belfast, united kingdom correspondence anna krasnodembskaya, phd, wellcomewolfson institute for experimental medicine. Stem cell therapy is emerging as a potentially revolution ary new way to treat. Allogeneic manufacturing of stem cells for therapies. Citescore values are based on citation counts in a given year. Helen blau on stem cells in the treatment of disease. Exosome secreted by msc reduces myocardial ischemiareperfusion injury open archive. To make hydrogels a more suitable environment for stem cells, fibrinlike and other cell. Introduction to stem cell therapy pubmed central pmc. Generation of an induced pluripotent stem cell line shcdni001a from a oneyearold chinese girl with mitochondrial dna depletion syndrome. The development of treatment methods has evoked great expectations. Read our pledge formalizing our commitment to strong representation of women scientists on our journal advisory boards. The article is accompanied by a slide show, an illustrated glossary, and an audio interview with one of the authors. Wed like to understand how you use our websites in order to improve them. Stem cells applications in regenerative medicine and disease.
Stem cell research is dedicated to publishing highquality manuscripts focusing on the biology and applications of stem cell research. The journal publishes key, wellcontrolled advances in stem cell clinical trials and mechanismbased manuscripts with definitive conclusions. Submissions to stem cell research, may cover all aspects of stem cells, including embryonic stem cells, tissuespecific stem cells, cancer stem cells. The spectacular progress in the field of stem cell research has laid the foundation for cell based therapies of disease which cannot be cured by conventional. Candidate es and eg cell lines from the human blastocyst and embryonic gonad can differentiate into multiple types of somatic cell. The study of these mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self. Stem cells focuses primarily on the functional and mechanistic aspects of stem cell biology and the potential of different types of stem cells for therapeutic applications. Stem cells and development is globally recognized as the trusted source for critical, even controversial coverage of emerging hypotheses and novel findings. Generation of the human induced pluripotent stem cell line ukwnli002a from dermal fibroblasts of a woman with a heterozygous c. Pdf the proliferation and differentiation of stem cell journals.
The journal is dedicated to publish quality articles with an emphasis on basic, translational and clinical research on stem cell. Blood and marrow stem cell transplantation guide i 3 part 1 understanding stem cell transplantation for thousands of people with blood cancers, stem cell transplantation sct is. Yet, many fundamental questions regarding the specific roles of stem cell in cancer progression and therapy remain elusive, impeding the effective clinical translation of stem cell. Human ips cells were similar to human embryonic stem. Updated list of high journal impact factor stem cell journals. Indian journal of human genetics januaryapril 2006 volume 12 issue 1.
Rapid advances in the isolation of multipotent progenitor cells, routinely called mesenchymal stromal stem cells mscs, from various human tissues and organs have provided impetus to the field of cell. Human embryonic stem cells journal of cell science. Pdf as scientists position themselves in translating the therapeutic potential of stem cells from laboratory to clinical applications, publishing. Generation of the induced pluripotent stem cell line uhomi001a from a patient with mutations in ccdc40 gene causing primary ciliary dyskinesia pcd engi ahmed, caroline sansac, mathieu fieldes, anne bergougnoux. Generation of an integrationfree induced pluripotent stem cell line pumchi001a from a patient with familial partial lipodystrophy type 2 fpld2 carrying a heterozygous p. Unipotent stem cells form only one type of specialized cell type.
Stem cells have great potential in tissue regeneration and repair but much. The influence of fibroblast growth factor 2 on the senescence of human adiposederived mesenchymal stem cells during longterm culture. Introducing cell reports medicine read the first online papers. Stem cell therapy in treatment of different dis eases 84 acta medica iranica, vol. Pdf stem cell therapy in treatment of different diseases.
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